Difference between revisions of "19: Bret Weinstein - The Prediction and the DISC"
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19: Bret Weinstein - The Prediction and the DISC (view source)
Revision as of 00:26, 19 February 2020
, 00:26, 19 February 2020→Transcript
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'''Bret:''' Mus musculus, which is the common one. What shocked me was that it turned out all the mus musculus that were being used in labs across the country, and in many cases, farther afield than that were coming from one place, which I had no idea. There was one— | '''Bret:''' Mus musculus, which is the common one. What shocked me was that it turned out all the mus musculus that were being used in labs across the country, and in many cases, farther afield than that were coming from one place, which I had no idea. There was one— | ||
'''Eric:''' I remember getting a phone call when you said, what do you know about | '''Eric:''' I remember getting a phone call when you said, what do you know about the [https://en.wikipedia.org/wiki/Jackson_Laboratory Jax lab]? | ||
'''Bret:''' The Jax lab in Bar Harbor Maine, right? They seemed to be the source of everybody's mice. And so it began to be—it was a possibility I could not shut down in my mind, that there was something about what was going on at the Jax lab that had resulted in the mice that were being sent out to all these other labs— | '''Bret:''' The [https://en.wikipedia.org/wiki/Jackson_Laboratory Jax lab] in Bar Harbor Maine, right? They seemed to be the source of everybody's mice. And so it began to be—it was a possibility I could not shut down in my mind, that there was something about what was going on at the Jax lab that had resulted in the mice that were being sent out to all these other labs— | ||
'''Eric:''' Is it that they were representative animals— | '''Eric:''' Is it that they were representative animals— | ||
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(01:12:04) | (01:12:04) | ||
'''Bret:''' Right, these are a model organism. People were just using mice because mice were a convenient mammal, but they're all coming from one place, and it began to occur to me that that one place was not just a source of mice in the sense that we might think it, it was actually a selective environment that was impacting those mice. And when I dug deeper, it turned out that the mice had all, they were descendants of a long lineage that had lived in captivity under conditions at the Jax lab. And at some point I realized that the most likely thing going on was that there was something about this environment that had wildly elongated the telomeres of these mice. And that was simultaneously an unbelievable idea, but the only one I could think of that made sense of everything I had seen. And so— | '''Bret:''' Right, these are a model organism. People were just using mice because mice were a convenient mammal, but they're all coming from one place, and it began to occur to me that that one place was not just a source of mice in the sense that we might think it, it was actually a selective environment that was impacting those mice. And when I dug deeper, it turned out that the mice had all, they were descendants of a long lineage that had lived in captivity under conditions at the [https://en.wikipedia.org/wiki/Jackson_Laboratory Jax lab]. And at some point I realized that the most likely thing going on was that there was something about this environment that had wildly elongated the telomeres of these mice. And that was simultaneously an unbelievable idea, but the only one I could think of that made sense of everything I had seen. And so— | ||
'''Eric:''' Well, it's unbelievable because the consequences, I mean, look, I have not even heard whether anyone has said, “Yeah, we did that, we screwed that up.” But it is, like, your favorite model organism for mammalian trials being screwed up by a central facility. Because also there's this weird thing where medical people very often stop taking into account evolutionary theory because they treat that as “Well, that's that class I took in college or the beginning of graduate school.” | '''Eric:''' Well, it's unbelievable because the consequences, I mean, look, I have not even heard whether anyone has said, “Yeah, we did that, we screwed that up.” But it is, like, your favorite model organism for mammalian trials being screwed up by a central facility. Because also there's this weird thing where medical people very often stop taking into account evolutionary theory because they treat that as “Well, that's that class I took in college or the beginning of graduate school.” | ||