Difference between revisions of "19: Bret Weinstein - The Prediction and the DISC"

'''Eric:''' I remember getting a phone call when you said, what do you know about the [https://en.wikipedia.org/wiki/Jackson_Laboratory Jax lab]?

'''Bret:''' The [https://en.wikipedia.org/wiki/Jackson_Laboratory Jax lab] in Bar Harbor Maine, right? They seemed to be the source of everybody's mice. And so it began to be—it was a possibility I could not shut down in my mind, that there was something about what was going on at the Jax lab that had resulted in the mice that were being sent out to all these other labs—

'''Bret:''' Right, these are a model organism. People were just using mice because mice were a convenient mammal, but they're all coming from one place, and it began to occur to me that that one place was not just a source of mice in the sense that we might think it, it was actually a selective environment that was impacting those mice. And when I dug deeper, it turned out that the mice had all, they were descendants of a long lineage that had lived in captivity under conditions at the [https://en.wikipedia.org/wiki/Jackson_Laboratory Jax lab]. And at some point I realized that the most likely thing going on was that there was something about this environment that had wildly elongated the telomeres of these mice. And that was simultaneously an unbelievable idea, but the only one I could think of that made sense of everything I had seen. And so—

'''Bret:''' [https://en.wikipedia.org/wiki/Elizabeth_Blackburn Elizabeth Blackburn]. Exactly. She was her student and they shared the Nobel prize with [https://en.wikipedia.org/wiki/Jack_W._Szostak Szostak]. In any case, her work seemed good to me. I called her up, cold, you know, I went into the insect division office and I sat down at the phone. I called her, I said, Carol, you don't know me. I'm a graduate student at Michigan. I'm an evolutionary biologist. I'm racking my brains trying to understand something. Can you tell me, is it possible that mice don't have ultra long telomeres? That it's only laboratory mice that do? And she said, huh, that's really interesting. I'm pretty sure that mice have long telomeres universally. But it is odd that if you order mus spretus instead of mus musculus and you order from European suppliers, the lengths are very different than what you get if you order mus musculus from the Jax club. I said, Whoa.

'''Bret:''' Right. But there's more to the Nobel lecture. So she spends her Nobel lecture on what is admittedly a very beautiful presentation of the connection between telomeres and senescence. She goes through tissue after tissue, says cirrhosis of the liver is what happens when you have short telomeres and your liver, etc. She goes through tissue after tissue. She projects the data, the blot actually from the paper with Mike Hemann, the paper that I should have been a coauthor on, she projects it on the screen, but she does some weird freaking dance, where she, instead of describing the long telomeres of laboratory mice as a major bug in the system, she describes it as a happy accident, effectively, because it allows us to test certain things like, “Oh, isn't it delightful that they have long telomeres?” And it's like, what the hell are you doing? There is so much riding on correcting this and you're presenting it like it’s just a bonus. And she, in her presentation, she's got several experiments that I did not know she had run that I had suggested to her and I said, you know, things like, “Carol, do you have any idea if a cell has many different telomere lengths, is it the shortest telomere that controls how many reproductions a cell can do?” She's run that experiment. Interesting. Low and behold, it's the shortest telomere. It's a good guess. But anyway, so, she goes through this. There's no mention of me, there's no mention of the actual implications of the the long telomeres for things like science and safety testing and all of that. And I can't seem to raise the issue of the safety question with anybody. Right? At best, I get journalists who are interested until they call somebody, and the somebodies on the other end, I know what they say. They say “everybody that mice aren't great models”. In fact, there's a paper out there that says something like the mice lie. It's not about this issue. It's just about the fact that mice aren't a perfect match. The issue in question could be solved. It could be addressed thoroughly. And, for all I know, once the Jax lab figured out what they were doing—